Adenovirus Hepatitis in Children 2022

Progress: 100%
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Clusters of acute hepatitis in kids—many resulting in liver failure—in Europe and the United States are triggering investigations from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), as the illnesses appear to be linked to infections with adenoviruses, in particular Adenovirus 41. The New Jersey Department of Health (NJDOH) is working in concert with CDC to better characterize and understand this illness in New Jersey,

Children with this condition typically present to healthcare providers with markedly elevated liver enzymes, often with jaundice, and they sometimes have gastrointestinal symptoms, including vomiting. Illness is severe enough that liver transplant is sometimes required.


New Jersey providers are encouraged to report cases using this form of acute hepatitis of unknown etiology (with OR without positive adenovirus testing) in children < 10 years of age.  Cases may be either current patients, or those in the past that meet these general criteria. You may be contacted to provide for additional information.


Note that this is a secure survey, and that personally identifiable information is protected. In addition, under HIPAA disclosures are permitted to public health authorities authorized by law to collect or receive such information for the purpose of preventing or controlling disease, injury, or disability.  45 C.F.R. § 164.512(b)(1)(i).  As such, an individual’s authorization is not required for the release of Protected Health Information to a public health authority conducting a public health investigation into a disease.  


For up-to-date information related to this investigation, please visit



Your name (or person to be contacted) ✱ required
First name
Last name
Name of facility/practice
Phone number (include area code)
Preferred email
Patient name ✱ required
First name
Last name
Patient address and phone ✱ required
Street address
Zip Code
Phone number (with area code)
Patient date of birth ✱ required
Patient sex (at birth) ✱ required
Patient race ✱ required
Patient ethnicity ✱ required
Approximate date of illness onset/Date first became ill ✱ required
Signs and Symptoms (check all that apply) ✱ required
Results of laboratory test for adenovirus ✱ required
Please provide the following labs if available. If more than one such lab was obtained, please include the largest value to date.
Were the following potential causes of hepatitis ruled out?
Ruled OutPendingNot assessedUnknown
Hepatitis A/B/C
Medication Toxicity
Autoimmune Hepatitis
Please indicate if the patient had a NEGATIVE test ruling out acute infection/involvement with any of the following (check all that apply) ✱ required
Please submit any laboratory test results in the file upload option at the end of the survey
Was the patient hospitalized? ✱ required
Did the patient experience any severe complications or outcomes? ✱ required
What is that patient's current status?
Please upload any pertinent part of the patient's medical record (e.g. case summary, consultant reports) as well as and laboratory test results
First file
Second file

Please provide any additional information you believe would be useful to this investigation for example potential exposures, clinical course of illness, biopsy results, etc.

Thank you for providing this important information. The NJDOH may follow-up if there are additional questions.